p63 and p73, the Ancestors of p53 | Zendy

Volker Dötsch | Zendy; Francesca Bernassola | Zendy; Daniel Coutandin | Zendy; Eleonora Candi | Zendy; Gerry Melino | Zendy

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p63 and p73, the Ancestors of p53

Author(s) -

Volker Dötsch,

Francesca Bernassola,

Daniel Coutandin,

Eleonora Candi,

Gerry Melino

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a004887

Subject(s) - biology , transcription factor , carcinogenesis , phenotype , promoter , transcription (linguistics) , genetics , knockout mouse , microbiology and biotechnology , gene , gene expression , linguistics , philosophy

p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the high degree of structural similarity shared by the p53 family members, p73 and p63 can bind and activate transcription from the majority of the p53-responsive promoters. Besides overlapping functions shared with p53 (i.e., induction of apoptosis in response to cellular stress), the existence of extensive structural variability within the family determines unique roles for p63 and p73. Their crucial and specific functions in controlling development and differentiation are well exemplified by the p63 and p73 knockout mouse phenotypes. Here, we describe the contribution of p63 and p73 to human pathology with emphasis on their roles in tumorigenesis and development

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