Aptamers and the RNA World, Past and Present | Zendy

Larry Gold | Zendy; Nebojša Janjić | Zendy; Thale C. Jarvis | Zendy; Dana Schneider | Zendy; Jeffrey J. Walker | Zendy; Sheri K. Wilcox | Zendy; Dom Zichi | Zendy

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Aptamers and the RNA World, Past and Present

Author(s) -

Larry Gold,

Nebojša Janjić,

Thale C. Jarvis,

Dana Schneider,

Jeffrey J. Walker,

Sheri K. Wilcox,

Dom Zichi

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a003582

Subject(s) - aptamer , biology , systematic evolution of ligands by exponential enrichment , the renaissance , computational biology , rna , rna world hypothesis , evolutionary biology , genetics , gene , art , ribozyme , art history

Aptamers and the SELEX process were discovered over two decades ago. These discoveries have spawned a productive academic and commercial industry. The collective results provide insights into biology, past and present, through an in vitro evolutionary exploration of the nature of nucleic acids and their potential roles in ancient life. Aptamers have helped usher in an RNA renaissance. Here we explore some of the evolution of the aptamer field and the insights it has provided for conceptualizing an RNA world, from its nascence to our current endeavor employing aptamers in human proteomics to discover biomarkers of health and disease.

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