Higher-order Genome Organization in Human Disease | Zendy

Tom Misteli | Zendy

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Higher-order Genome Organization in Human Disease

Author(s) -

Tom Misteli

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a000794

Subject(s) - biology , chromatin , genome , scaffold/matrix attachment region , genomic organization , gene , chia pet , genetics , bivalent chromatin , computational biology , regulation of gene expression , human genome , chromosome , chromatin remodeling

Genomes are organized into complex higher-order structures by folding of the DNA into chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order organization of genomes is functionally important for gene regulation and control of gene expression programs. Defects in how chromatin is globally organized are relevant for physiological and pathological processes. Mutations and transcriptional misregulation of several global genome organizers are linked to human diseases and global alterations in chromatin structure are emerging as key players in maintenance of genome stability, aging, and the formation of cancer translocations.

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