7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity | Zendy

Auri R. Duval | Zendy; Pedro Henrique de Azambuja Carvalho | Zendy; Maieli C. Soares | Zendy; Daniela P. Gouvêa | Zendy; Geonir M. Siqueira | Zendy; Rafael Guerra Lund | Zendy; Wilson Cúnico | Zendy

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7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity

Author(s) -

Auri R. Duval,

Pedro Henrique de Azambuja Carvalho,

Maieli C. Soares,

Daniela P. Gouvêa,

Geonir M. Siqueira,

Rafael Guerra Lund,

Wilson Cúnico

Publication year - 2011

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2011.141

Subject(s) - minimum inhibitory concentration , fluconazole , antifungal , candida glabrata , candida tropicalis , candida albicans , fungicide , corpus albicans , chemistry , microbiology and biotechnology , candida parapsilosis , in vitro , biology , biochemistry , botany

Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents.

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