The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases | Zendy

Simon J. Conway | Zendy; Thomas Doetschman | Zendy; Mohamad Azhar | Zendy

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The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases

Author(s) -

Simon J. Conway,

Thomas Doetschman,

Mohamad Azhar

Publication year - 2011

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2011.132

Subject(s) - periostin , heart valve , context (archaeology) , transforming growth factor beta , medicine , bone morphogenetic protein , valvular heart disease , transforming growth factor , cardiology , microbiology and biotechnology , biology , gene , genetics , paleontology , extracellular matrix

Recent studies have suggested an important role for periostin and transforming growth factor beta (TGF beta) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGF beta and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGF beta and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.

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