Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease | Zendy

Shiv K. Sharma | Zendy

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Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease

Author(s) -

Shiv K. Sharma

Publication year - 2010

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2010.49

Subject(s) - hepatocyte growth factor , synaptic plasticity , receptor tyrosine kinase , neuroscience , microbiology and biotechnology , hippocampal formation , hepatocyte growth factor receptor , biology , tyrosine kinase , signal transduction , c met , receptor , cancer research , biochemistry

The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development. HGF and its receptor are also present in brain cells. This review describes the role of HGF in hippocampal neurons, synaptic plasticity, and the memory impairment condition, Alzheimer's disease.

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