Ca2+Signaling in B Cells | Zendy

Taras Lyubchenko | Zendy

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Ca2+Signaling in B Cells

Author(s) -

Taras Lyubchenko

Publication year - 2010

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2010.219

Subject(s) - breakpoint cluster region , microbiology and biotechnology , cell signaling , signal transduction , intracellular , phosphorylation , immunological synapse , calcium signaling , b cell receptor , receptor , biology , immune system , chemistry , t cell , b cell , immunology , t cell receptor , biochemistry , antibody

An increase in intracellular Ca²+ concentration is one of the major initial steps in B-cell activation that occurs within minutes after antigen receptor (BCR) engagement. In recent years, significant advances have been made in characterizing molecular mechanisms of Ca²+ signaling in lymphocytes, although the majority of work was done on T cells. This mini-review discusses several underexplored areas of Ca²+ signaling in B cells: (1) Ca²+ signaling in immune synapse and multifaceted Ca²+ responses within a single cell, (2) source of Ca²+ involved in Ca²+-dependent protein phosphorylation events and the role of store-operated influx, (3) role of BCR coreceptors in Ca²+ signaling, and (4) Ca²+ signaling and maintenance of B-cell tolerance and clinical significance of Ca²+ signaling alterations.

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