Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma | Zendy

Carla E. Cano | Zendy; Yoshiharu Motoo | Zendy; Juan Iovanna | Zendy

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Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma

Author(s) -

Carla E. Cano,

Yoshiharu Motoo,

Juan Iovanna

Publication year - 2010

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2010.183

Subject(s) - epithelial–mesenchymal transition , pancreatic cancer , mesenchymal stem cell , cancer research , phenotype , adenocarcinoma , cancer , biology , cancer cell , medicine , pathology , metastasis , gene , genetics

Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by various tumor microenvironmental factors, including cytokines, growth factors, and chemotherapeutic agents. This review summarizes the state-of-the-art knowledge on the molecular mechanisms that support pancreatic cancer EMT and the evidences that support its involvement in invasiveness/ aggressiveness, and the drug resistance of pancreatic cancer cells.

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