FHITDoubts are Clear Now | Zendy

Anjilna Wali | Zendy

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FHITDoubts are Clear Now

Author(s) -

Anjilna Wali

Publication year - 2010

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2010.110

Subject(s) - fhit , loss of heterozygosity , gene , biology , tumor suppressor gene , cancer research , cytoplasm , mitochondrion , cell , suppressor , genetics , carcinogenesis , allele

The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm of chromosome 3 and its loss of function has been evaluated in different types of cancers. Loss of heterozygosity at various sections of the FHIT gene and the methylation analysis of the promoter region showed that it is one of the important and preliminary genetic alterations in the cell, and its restoration in the cell line or nude mice suppresses tumorigenicity. Current research on the FHIT gene has depicted that Fhit interacts with different proteins through different pathways in the nucleus, mitochondria, and cytoplasm, directing the cell to apoptosis.

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