Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing | Zendy

Laura Trapani | Zendy; Valentina Pallottini | Zendy

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Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing

Author(s) -

Laura Trapani,

Valentina Pallottini

Publication year - 2009

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2009.81

Subject(s) - reductase , coenzyme a , ageing , cholesterol synthesis , cholesterol , hmg coa reductase , hydroxymethylglutaryl coa reductase , enzyme , homeostasis , chemistry , endocrinology , biochemistry , medicine , biology

We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effect exerted on some enzyme regulation. Some mechanisms underlying hypercholesterolemia onset and, in particular, the role and the regulation of 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) during adult life and during aging, have been described. In addition some pharmacological interventions to control proper HMGR regulation and, in turn, cholesterol homeostasis maintenance will be introduced.

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