Spinal Cord Injury Research in Mice: 2008 Review | Zendy

Inge Steuer | Zendy; Pierre A. Guertin | Zendy

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Spinal Cord Injury Research in Mice: 2008 Review

Author(s) -

Inge Steuer,

Pierre A. Guertin

Publication year - 2009

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2009.63

Subject(s) - spinal cord injury , spinal cord , neuroscience , medicine , neuromodulation , regeneration (biology) , lesion , physical medicine and rehabilitation , bioinformatics , biology , pathology , central nervous system , microbiology and biotechnology

Spinal cord injury (SCI) is an irreversible condition causing damage to myelinated fiber tracts that carry sensation and motor signals to and from the brain. SCI is also associated with gray matter damage and often life-threatening secondary complications. This mini-review aims to provide the nonspecialist reader with a comprehensive description of recent advances made in 2008 using murine models of SCI. A variety of approaches, including advanced genetics and molecular techniques, have allowed a number of key findings in the field of secondary degeneration, repair, regeneration (including insights from peripheral nerve lesion models), metabolic dysfunctions, and pharmacological neuromodulation.

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