Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging Research | Zendy

Baomin Li | Zendy; Sonali P. Jog | Zendy; José Candelario | Zendy; Sita Reddy | Zendy; Lucio Comai | Zendy

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Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging Research

Author(s) -

Baomin Li,

Sonali P. Jog,

José Candelario,

Sita Reddy,

Lucio Comai

Publication year - 2009

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2009.159

Subject(s) - progeria , werner syndrome , cellular aging , population , biology , gerontology , neuroscience , medicine , genetics , telomere , helicase , dna , rna , gene , environmental health

Syndromes of accelerated aging could provide an entry point for identifying and dissecting the cellular pathways that are involved in the development of age-related pathologies in the general population. However, their usefulness for aging research has been controversial, as it has been argued that these diseases do not faithfully reflect the process of natural aging. Here we review recent findings on the molecular basis of two progeroid diseases, Werner syndrome (WS) and Hutchinson-Gilford progeria syndrome (HGPS), and highlight functional connections to cellular processes that may contribute to normal aging.

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