Characterization of a PLLA-Collagen I Blend Nanofiber Scaffold with Respect to Growth and Osteogenic Differentiation of Human Mesenchymal Stem Cells | Zendy

Markus D. Schofer | Zendy; Ulrich Boudriot | Zendy; Irini Leifeld | Zendy; Romina I. Sütterlin | Zendy; Markus Rudisile | Zendy; Joachim H. Wendorff | Zendy; Andreas Greiner | Zendy; Jürgen R. J. Paletta | Zendy; Susanne FuchsWinkelmann | Zendy

Open Access

Characterization of a PLLA-Collagen I Blend Nanofiber Scaffold with Respect to Growth and Osteogenic Differentiation of Human Mesenchymal Stem Cells

Author(s) -

Markus D. Schofer,

Ulrich Boudriot,

Irini Leifeld,

Romina I. Sütterlin,

Markus Rudisile,

Joachim H. Wendorff,

Andreas Greiner,

Jürgen R. J. Paletta,

Susanne FuchsWinkelmann

Publication year - 2009

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2009.13

Subject(s) - nanofiber , scaffold , mesenchymal stem cell , materials science , osteoblast , regeneration (biology) , tissue engineering , biomedical engineering , cell growth , nanotechnology , microbiology and biotechnology , chemistry , biology , in vitro , biochemistry , medicine

We developed a nanofiber scaffold by blending PLLA with collagen I, suitable for bone regeneration. Among several PLLA-COLI ratios tested, cell growth was better enhanced when blends with a ratio of PLLA-COLI 4:1 were used. Here, growth as well as osteoblast differentiation of hMSC was improved when compared to PLLA nanofibers alone. Therefore, blending is a suitable tool to enhance PLLA nanofibers with respect to bone tissue engineering.

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