Open AccessInflammatory Microenvironment Promotes Hemopoietic-Derived Angiogenic Cell Expansion and Arterial Specification
Author(s) -
Patrizia Dentelli,
Maria Felice Brizzi
Publication year - 2008
Publication title -
the scientific world journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.453
H-Index - 93
eISSN - 2356-6140
pISSN - 1537-744X
DOI - 10.1100/tsw.2008.142
Subject(s) - haematopoiesis , angiogenesis , microbiology and biotechnology , cytokine , stat5 , cancer research , computational biology , biology , immunology , signal transduction , stem cell
The manuscript deals with the effects exerted by the inflammatory microenvironment on angiogenic cell expansion and arterial specification. Data reported demonstrated that the inflammatory cytokine IL-3 expands a subset of hemopoietic-derived cells, which directly contribute to neovessel formation. In addition, the identification of STAT5 as a molecular signature of the vasculogenetic process provides the rationale for a novel therapeutic strategy to manipulate vascular growth.
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