The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition | Zendy

Emily Paterson | Zendy; Natasha Kolesnikoff | Zendy; Philip A. Gregory | Zendy; Andrew G. Bert | Zendy; Yeesim KhewGoodall | Zendy; Gregory J. Goodall | Zendy

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The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition

Author(s) -

Emily Paterson,

Natasha Kolesnikoff,

Philip A. Gregory,

Andrew G. Bert,

Yeesim KhewGoodall,

Gregory J. Goodall

Publication year - 2008

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2008.115

Subject(s) - microrna , epithelial–mesenchymal transition , metastasis , mesenchymal stem cell , cancer research , biology , breast cancer , transition (genetics) , breast cancer metastasis , cancer metastasis , microbiology and biotechnology , cancer , gene , genetics

Epithelial-mesenchymal transition (EMT) is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205. Expression of these miRNAs was lost in invasive breast cancer cell lines displaying mesenchymal-like morphology suggesting these microRNAs may play a role in cancer metastasis.

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