Proteoglycan Biosynthesis during Chondrogenic Differentiation of Mesenchymal Stem Cells | Zendy

C Götting | Zendy; Christian Prante | Zendy; Joachim Kühn | Zendy; K Kleesiek | Zendy

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Proteoglycan Biosynthesis during Chondrogenic Differentiation of Mesenchymal Stem Cells

Author(s) -

C Götting,

Christian Prante,

Joachim Kühn,

K Kleesiek

Publication year - 2007

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2007.231

Subject(s) - chondrogenesis , microbiology and biotechnology , mesenchymal stem cell , extracellular matrix , cartilage , progenitor cell , stem cell , proteoglycan , matrix (chemical analysis) , stem cell transplantation for articular cartilage repair , chemistry , cellular differentiation , biology , anatomy , adult stem cell , biochemistry , gene , chromatography

Mesenchymal stem cells are multipotent progenitor cells that can differentiate into the chondrogenic lineage. To date, only limited knowledge about the formation and remodeling of the cartilaginous extracellular matrix is available. We recently analyzed the coordinated expression of proteins involved in the biosynthesis of proteoglycans and collagens, the two major components of cartilage matrix, to understand matrix formation and to provide potential tools to improve the quality of tissue-engineered cartilage.

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