Role of microRNA Pathway in Mental Retardation | Zendy

Abrar Qurashi | Zendy; Shuang Chang | Zendy; Peng Jin | Zendy

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Role of microRNA Pathway in Mental Retardation

Author(s) -

Abrar Qurashi,

Shuang Chang,

Peng Jin

Publication year - 2007

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2007.208

Subject(s) - fragile x syndrome , microrna , fragile x , pathogenesis , genetics , biology , bioinformatics , gene , medicine , computational biology , neuroscience , immunology

Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP). MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general.

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