Combined Effects of Estrogen and Mechanical Loading on Anterior Cruciate Ligament Fibroblast Biosynthesis | Zendy

Xuhui Liu | Zendy; ZongPing Luo | Zendy

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Combined Effects of Estrogen and Mechanical Loading on Anterior Cruciate Ligament Fibroblast Biosynthesis

Author(s) -

Xuhui Liu,

ZongPing Luo

Publication year - 2005

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2005.6

Subject(s) - anterior cruciate ligament , estrogen , extracellular matrix , fibroblast , biosynthesis , medicine , microbiology and biotechnology , chemistry , gene , biology , endocrinology , anatomy , cell culture , biochemistry , genetics

For some time, estrogen has been suspected to play a negative role in anterior cruciate ligament (ACL) fibroblast biosynthesis; however, reports on this issue have been controversial. In a recent study, our group demonstrated a negative combined effect of estrogen and mechanical loading on the gene expression of major extracellular matrix component molecules in ACL fibroblasts.

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