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. Genome sequencing projects have dramatically increased our understanding of the pathways and proteins involved in biological systems. The NAD(P)-utilizing family of enzymes is one of the most important gene families representing 15% of all known enzyme functions. We have performed a complete characterization of this gene family on a sequence, structural, and NAD(P)-pharmacophore level. Genome-wide analysis was performed to gain a complete understanding of the structures and functional importance of NAD(P)-utilizing enzymes in 17 different genomes.

Elucidation of Protein Structural and Pharmacophore Features Based on Sequence Clustering by Common Neighbor Comparisons