Procollagen-Like Protein as a Molecular Target in the Treatment of Primary Brain Tumor | Zendy

Medhi Wangpaichitr | Zendy; Howard J. Landy | Zendy; Chun Wu | Zendy; Lynn G. Feun | Zendy; Rong Xu | Zendy; Jenny Xu | Zendy; Niramol Savaraj | Zendy

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Procollagen-Like Protein as a Molecular Target in the Treatment of Primary Brain Tumor

Author(s) -

Medhi Wangpaichitr,

Howard J. Landy,

Chun Wu,

Lynn G. Feun,

Rong Xu,

Jenny Xu,

Niramol Savaraj

Publication year - 2002

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2002.59

Subject(s) - brain tumor , procollagen peptidase , primary (astronomy) , medicine , cancer research , bioinformatics , pathology , biology , physics , astronomy

METHODS. cDNA library was obtained in one glioma cell line which highly expressed this protein and screening was performed using VDR monoclonal antibody. This partial cDNA was then subcloned into pcDNA3.1 and sequencing was performed. This partial cDNA sequence also was used as a probe to identify mRNA, which encodes for this putative gene. To characterize this 220-Kd protein, we have used five cell lines as follows: Glioma 1, U118, SW1783, which possess variable amount of 220-Kd protein, and U-373 and T-98G which lack this 220-Kd protein.

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