Identification of Protein Folding Cores Using Charge Center Model of Protein Structure | Zendy

I. Yu. Torshin | Zendy; Robert W. Harrison | Zendy; Irene T. Weber | Zendy; John M. Petock | Zendy

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Identification of Protein Folding Cores Using Charge Center Model of Protein Structure

Author(s) -

I. Yu. Torshin,

Robert W. Harrison,

Irene T. Weber,

John M. Petock

Publication year - 2002

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2002.40

Subject(s) - identification (biology) , protein folding , folding (dsp implementation) , charge (physics) , center (category theory) , computer science , computational biology , chemistry , crystallography , physics , biology , biochemistry , botany , quantum mechanics , electrical engineering , engineering

This short communication introduces a novel method for identification of the folding cores in proteins. Positive and negative charge centers, defined solely from the structure of the folded protein are likely to indicate the protein's folding core. The residues and sequences, identified by the procedure, are highly consistent with the available biochemical data on folding as seen for a set of about 20 proteins. Here, the folding of chymotrypsin inhibitor-2 (CI2) from barley is analyzed in some detail.

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