OSTEOPONTIN IS INVOLVED IN THE INITIATION OF CUTANEOUS CONTACT HYPERSENSITIVITY BY INDUCING LANGERHANS AND DENDRITIC CELL MIGRATION TO LYMPH NODES | Zendy

Andreas C. Renkl | Zendy; Christoph Maier | Zendy; Martin Kimmig | Zendy; Lucy Liaw | Zendy; Tino Ahrens | Zendy; S Kon | Zendy; Masahiro Maeda | Zendy; Hiroshi Hotta | Zendy; T Uede | Zendy; Jan C. Simon | Zendy; J.M. Weiss | Zendy

Open Access

OSTEOPONTIN IS INVOLVED IN THE INITIATION OF CUTANEOUS CONTACT HYPERSENSITIVITY BY INDUCING LANGERHANS AND DENDRITIC CELL MIGRATION TO LYMPH NODES

Author(s) -

Andreas C. Renkl,

Christoph Maier,

Martin Kimmig,

Lucy Liaw,

Tino Ahrens,

S Kon,

Masahiro Maeda,

Hiroshi Hotta,

T Uede,

Jan C. Simon,

J.M. Weiss

Publication year - 2002

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Conference proceedings

DOI - 10.1100/tsw.2002.313

Subject(s) - osteopontin , lymph , dendritic cell , langerhans cell , cell , medicine , immunology , pathology , biology , antigen , genetics

Osteopontin (OPN) is a chemotactic protein that attracts immune cells, to inflammatory sites. The sensitization phase of allergic cutaneous contact hypersensitivity (CHS) requires the migration of Langerhans cells/dendritic cells (LCs/DCs) from skin to draining lymph nodes. Characterizing OPN function for LC/DC migration we found upregulated OPN expression in hapten sensitized skin and draining lymph nodes. OPN induces chemotactic LC/DC migration, initiates their emigration from the epidermis, and attracts LCs/DCs to draining lymph nodes by interacting with CD44 and αv integrin. Furthermore, OPN-deficient mice have a significantly reduced CHS response that correlates with an impaired ability of OPN-deficient mice to attract LCs/DCs to draining lymph nodes. In conclusion, OPN is an important factor in the initiation of CHS by guiding LCs/DCs from skin into lymphatic organs.

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