The Protein Trinity: Structure/Function Relationships That Include Intrinsic Disorder | Zendy

A. Keith Dunker | Zendy; Celeste J. Brown | Zendy; J. David Lawson | Zendy; Lilia M. Iakoucheva-Sebat | Zendy; Slobodan Vučetić | Zendy; Zoran Obradović | Zendy

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The Protein Trinity: Structure/Function Relationships That Include Intrinsic Disorder

Author(s) -

A. Keith Dunker,

Celeste J. Brown,

J. David Lawson,

Lilia M. Iakoucheva-Sebat,

Slobodan Vučetić,

Zoran Obradović

Publication year - 2002

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2002.25

Subject(s) - function (biology) , intrinsically disordered proteins , protein structure , computational biology , protein function , protein function prediction , peptide sequence , protein structure prediction , chemistry , biology , biophysics , biochemistry , microbiology and biotechnology , gene

. The current, dominant view relating protein structure to function can be expressed as amino acid sequence → 3-D structure → function. Currently, more than 200 counter examples in which function depends on nonfolded or incompletely folded regions of protein have been described. Furthermore, reviews on intrinsically disordered proteins are beginning to appear[1,2,3]. In one of these reviews, it is suggested that the existence of proteins with intrinsic protein disorder calls for a re-assessment of the protein structure-function paradigm[3].

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