Inteins in Microbial Genomes: Distribution, Mechanism, and Function | Zendy

Maurice W. Southworth | Zendy; Francine B. Perler | Zendy

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Inteins in Microbial Genomes: Distribution, Mechanism, and Function

Author(s) -

Maurice W. Southworth,

Francine B. Perler

Publication year - 2002

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2002.13

Subject(s) - intein , protein splicing , rna splicing , computational biology , genome , function (biology) , mechanism (biology) , biology , computer science , genetics , gene , rna , philosophy , epistemology

Inteins are self-splicing protein elements (134 to 608 amino acids). Over 125 inteins have been cataloged in InBase, the on-line intein database (http://www.neb.com/neb/inteins.html), which includes the Intein Registry[1]. Inteins naturally present in pathogenic microbes represent novel, yet unexploited drug targets. Understanding the chemistry of the splicing reaction has allowed the manipulation of inteins, which are now used in many protein engineering applications[2].

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