Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) | Zendy

Z. Razzaque | Zendy; David E. Shaw | Zendy; Mark G. Bock | Zendy; L. Maskell | Zendy; J. D. Pickard | Zendy; D. Sirinathsinghji | Zendy; J. Longmore | Zendy

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Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)

Author(s) -

Z. Razzaque,

David E. Shaw,

Mark G. Bock,

L. Maskell,

J. D. Pickard,

D. Sirinathsinghji,

J. Longmore

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.437

Subject(s) - calcitonin gene related peptide , adrenomedullin , amylin , receptor , middle meningeal artery , calcitonin , endocrinology , calcitonin receptor , medicine , chemistry , pharmacology , neuroscience , biology , neuropeptide , surgery , embolization , islet , insulin

Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA).

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