The Role of Cgrp-Receptor Component Protein (Rcp) in Cgrp-Mediated Signal Transduction | Zendy

Marco A. M. Prado | Zendy; B. Evans-Bain | Zendy; Spartaco Santi | Zendy; Ian M. Dickerson | Zendy

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The Role of Cgrp-Receptor Component Protein (Rcp) in Cgrp-Mediated Signal Transduction

Author(s) -

Marco A. M. Prado,

B. Evans-Bain,

Spartaco Santi,

Ian M. Dickerson

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.435

Subject(s) - calcitonin gene related peptide , signal transduction , receptor , microbiology and biotechnology , transduction (biophysics) , g protein coupled receptor , cell surface receptor , biology , chemistry , neuropeptide , biochemistry

The calcitonin gene-related peptide (CGRP)-receptor component protein (RCP) is a 17-kDa intracellular peripheral membrane protein required for signal transduction at CGRP receptors. To determine the role of RCP in CGRP-mediated signal transduction, RCP was depleted from NIH3T3 cells using antisense strategy. Loss of RCP protein correlated with loss of cAMP production by CGRP in the antisense cells. In contrast, loss of RCP had no effect on CGRP-mediated binding; therefore RCP is not acting as a chaperone for the CGRP receptor. Instead, RCP is a novel signal transduction molecule that couples the CGRP receptor to the cellular signal transduction machinery. RCP thus represents a prototype for a new class of signal transduction proteins that are required for regulation of G protein-coupled receptors.

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