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Enhanced Vasodilator Responses to CGRP (Calcitonin Gene-Related Peptide) in Subcutaneous Arteries in Human Hypertension
Author(s) -
Henrik Lind,
Lars Edvinsson
Publication year - 2001
Publication title -
the scientific world journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.453
H-Index - 93
eISSN - 2356-6140
pISSN - 1537-744X
DOI - 10.1100/tsw.2001.424
Subject(s) - calcitonin gene related peptide , vasodilation , calcitonin , medicine , endocrinology , peptide , pharmacology , neuropeptide , cardiology , chemistry , receptor , biochemistry
To evaluate alterations induced by essential and renovascular hypertension on vasomotoresponse to CGRP, substance P, potassium and noradrenaline human subcutaneous vessels were studied. Isolated segments (1 to 2 mm) of small subcutaneous arteries (diameter 0.1 to 0.9 mm) and veins (0.1 to 1.0 mm) with intact endothelium from patients (essential n = 10, renovascular n = 6) and controls (n = 17) were used.

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