Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP | Zendy

Jaebeom Lee | Zendy; Ronald B. Emeson | Zendy

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Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP

Author(s) -

Jaebeom Lee,

Ronald B. Emeson

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.423

Subject(s) - calcitonin gene related peptide , neurotransmitter , neuroscience , neurogenic inflammation , acetylcholine , calcitonin , receptor , nociception , neurotransmitter agents , neuropeptide , peripheral , inflammation , central nervous system , biology , medicine , pharmacology , substance p , microbiology and biotechnology , endocrinology

a-Calcitonin gene-related peptide (aCGRP) is a pleiotropic peptide neuromodulator that is widely expressed throughout the central and peripheral nervous systems. Although CGRP has been implicated in numerous physiological processes (including peripheral vasodilatation, acetylcholine receptor biosynthesis, nociception, and neurogenic inflammation), the precise physiological roles of CGRP remain to be elucidated. To provide a better understanding of the physiological role(s) mediated by this peptide neurotransmitter, we have generated aCGRP-null mice by targeted modification in embryonic stem cells.

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