PAK-2 Targeting to Mitochondria and Cleavage by Caspases Induces Apoptosis | Zendy

Thomas Rudel | Zendy; Kathrin Laumlttig | Zendy; Nikolaus Machuy | Zendy; Tabita Manke | Zendy; Anne Muumuller | Zendy; Oliver Thieck | Zendy

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PAK-2 Targeting to Mitochondria and Cleavage by Caspases Induces Apoptosis

Author(s) -

Thomas Rudel,

Kathrin Laumlttig,

Nikolaus Machuy,

Tabita Manke,

Anne Muumuller,

Oliver Thieck

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.245

Subject(s) - apoptosis , caspase , cleavage (geology) , mitochondrion , microbiology and biotechnology , intrinsic apoptosis , chemistry , biology , programmed cell death , biochemistry , paleontology , fracture (geology)

METHODS. cDNAs encoding wild type (WT) or mutant PAK-1 or PAK-2 were transfected into different cell lines. Mitochondrial localization was monitored by biochemical methods and by confocal microscopy. WT and mutant PAKs were artificially targeted to cellular compartments by the addition of targeting signals to the Nor C-terminus. Apoptosis was monitored by microscopy and immunostaining of cytochrome c or active caspase-3.

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