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. Caspases are a family of cysteine aspartyl proteases that are involved in the cleavage of key structural, cell signaling, and DNA repair substrates leading to apoptotic cell death (1). As a result, the modulation of caspase response is the object of intense study in clinical research. Caspase 3 is recognized as a pivotal effector and logical target for therapeutic intervention (2). To this end, we have developed a robust, highly sensitive, and rapid homogeneous caspase 3 assay that is quantifiable in cell-based assays and with purified active caspase 3. We have used this assay to monitor the efficiency of several cell-permeable caspase 3 inhibitors in the cell-based Jurkat/Fas-induction model system (3). The evaluation of these compounds by caspase activity was supported and correlated with the CaspACE FITCVAD-FMK in situ cell imaging assay.

Single Step Fluorescent Caspase 3 Activity Assay: Quantifying the Inhibition of Cell Permeable Compounds in a Cell-Based System