DNA Methyltransferase I (DNMT1) Inhibition Induces a p21 Dependent Cell Cycle Arrest | Zendy

Juan I. Young | Zendy; James R. Smith | Zendy

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DNA Methyltransferase I (DNMT1) Inhibition Induces a p21 Dependent Cell Cycle Arrest

Author(s) -

Juan I. Young,

James R. Smith

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.232

Subject(s) - dnmt1 , cell cycle checkpoint , methyltransferase , cell cycle , dna methyltransferase , microbiology and biotechnology , dna , chemistry , biology , cell , biochemistry , methylation

The cyclin dependent kinase (Cdk) inhibitor p21 plays an essential role in the establishment of the senescent state. It inactivates most of the Cdk-cyclin complexes producing an accumulation of hypophosphorylated Rb no longer able to repress E2f responsive genes. Cloned as a senescent gene, p21 expression increases during in vitro aging. Underscoring its role in senescence, disruption of the p21 gene enables normal human fibroblasts to bypass senescence (2).

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