Glutathione Biosynthesis Influences Replicative Longevity in Saccharomyces Cerevisiae | Zendy

Sylvie M. Van Zandycke | Zendy; Katherine A. Smart | Zendy

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Glutathione Biosynthesis Influences Replicative Longevity in Saccharomyces Cerevisiae

Author(s) -

Sylvie M. Van Zandycke,

Katherine A. Smart

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.231

Subject(s) - longevity , saccharomyces cerevisiae , glutathione , biosynthesis , biochemistry , chemistry , biology , genetics , yeast , gene , enzyme

. The yeast Saccharomyces cerevisiae possesses a finite lifespan; the metric of which is the number of times the cell divides and not its chronological age (1). The free radical theory of ageing postulates that reactive oxygen species are causal factors in ageing (2). These species are capable of damaging DNA, protein and lipids within the cell. For defence against these prooxidants, cells contain antioxidant molecule such as glutathione (GSH).

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