Genetic Mapping of Cell Survival Pathways using Enhanced Retroviral Mutagens

. Apoptosis and survival play a crucial role in mammalian development. However the signaling pathways for survival are much less well understood compared to apoptosis pathways. The mammalian cell survival factors known to date have been largely identified either biochemically or based on genetic studies in other organisms. Efficient and effective genetic methods that allow systematic studies of anti-apoptosis genes in mammalian cells remain to be established.