Anticancer Drug-Induced Apoptosis and Cytotoxicity in Prostate Cancer Cells Are Modulated by Organ-Specific Stromal Cell Factors | Zendy

Bal L. Lokeshwar | Zendy; Kamalaveni R. Prabhakar | Zendy; Tie Yan Shang | Zendy; Zafiria Mourelatos | Zendy; Dequan Li | Zendy

Open Access

Anticancer Drug-Induced Apoptosis and Cytotoxicity in Prostate Cancer Cells Are Modulated by Organ-Specific Stromal Cell Factors

Author(s) -

Bal L. Lokeshwar,

Kamalaveni R. Prabhakar,

Tie Yan Shang,

Zafiria Mourelatos,

Dequan Li

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.168

Subject(s) - stromal cell , cytotoxicity , apoptosis , cancer research , prostate cancer , prostate , drug , cancer , medicine , chemistry , pharmacology , biochemistry , in vitro

. Most anticancer drugs kill tumor cells by inducing apoptotic cell death [1]. Enhancement of this apoptosis-inducing activity or overcoming tumor's resistance to apoptosis induction by anticancer drugs could bring a significant improvement in cancer therapy. Cytokines and tissue-specific factors mediate communication between tumor cells and surrounding stromal cells [2,3]. These agents are believed also to modulate tumor cells' response to anti-cancer drugs. This phenomenon is predominantly acute in metastatic prostate cancer, where most patients with metastatic disease survive less than 3 years. The purpose of this study was to examine the impact of stromal cells (fibroblast and endothelial cells)-induced cytokines on the response of tumor cells to anticancer drugs.

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