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. Chemoresistance is a major impediment to the successful treatment of cancer. However, the mechanisms of chemoresistance are poorly understood. Cisplatin (CDDP) treatment activates multiple signal transduction pathways that can lead to diverse cellular responses, including cell cycle arrest (G2/M), DNA repair, or apoptosis. Differences in early signal transduction activity in response to chemotherapy could provide insight regarding the ultimate outcome of treatment. In this study, we attempted to elucidate the mechanisms of resistance to cisplatin in a cisplatin-sensitive human ovarian cancer cell line and a cisplatinresistant clone (2008 and 2008.C13 respectively).

Activation of the JNK/SAPK and P38 Mitogen-Activated Protein Kinase Signaling Pathways Sensitize Tumor Cells to Cisplatin-Induced Apoptosis