Nitric Oxide Protects Mouse Thymocytes from Apoptosis Induced by γ-Irradiation | Zendy

Yue Chen | Zendy; Ala Stanford | Zendy; Rosie Hoffman | Zendy; Henri R. Ford | Zendy

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Nitric Oxide Protects Mouse Thymocytes from Apoptosis Induced by γ-Irradiation

Author(s) -

Yue Chen,

Ala Stanford,

Rosie Hoffman,

Henri R. Ford

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.158

Subject(s) - nitric oxide , apoptosis , irradiation , microbiology and biotechnology , chemistry , biophysics , biology , biochemistry , physics , nuclear physics , organic chemistry

. Nitric Oxide (NO) and its reactive products can either promote or prevent apoptosis depending upon the cell systems and conditions involved (1). We have previously reported that NO-induced mouse thymocyte apoptosis in vitro involves p53 upregulation and caspase-1 activation (2, 3). To further dissect the relationship between NO and thymocyte apoptosis, we investigated the effect of NO on Balb/c thymocytes exposed to γ-irradiation. We found that NO partially protects γ-irradiated thymocytes from apoptosis by preserving mitochondrial integrity and inhibiting caspase activity.

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