Establishment of Okadaic Acid Resistant Cell Clones using CDNA Library Expression Cloning | Zendy

Tone Sandal | Zendy; Johan R. Lillehaug | Zendy; Stein Ove D skeland | Zendy; Ragnhild Ahlgren | Zendy

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Establishment of Okadaic Acid Resistant Cell Clones using CDNA Library Expression Cloning

Author(s) -

Tone Sandal,

Johan R. Lillehaug,

Stein Ove D skeland,

Ragnhild Ahlgren

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.149

Subject(s) - okadaic acid , cloning (programming) , expression cloning , complementary dna , cdna library , genomic library , library , microbiology and biotechnology , biology , computational biology , genetics , gene , computer science , base sequence , phosphatase , phosphorylation , programming language , 16s ribosomal rna

. The broad action of the phosphatases inhibited by this universal apoptogen has made it difficult to pinpoint the relevant molecular targets, and mechanisms involved in OA induced apoptosis(1,2,3,4). Retroviral cDNA-library expression cloning technique (5) report the isolation of more than twenty OA resistant cell clones, and characterisation of two of them reveals that the approach can produce OA resistant cell clones to be used as important tools to investigate mechanisms of apoptosis induced by serine/threonine phosphatase inhibitors.

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