Longevity and Stem Cells: A Genetic Connection | Zendy

Hartmut Geiger | Zendy; Jarrod M. True | Zendy; Gerald de Haan | Zendy; Gary Van Zant | Zendy

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Longevity and Stem Cells: A Genetic Connection

Author(s) -

Hartmut Geiger,

Jarrod M. True,

Gerald de Haan,

Gary Van Zant

Publication year - 2001

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/tsw.2001.136

Subject(s) - longevity , connection (principal bundle) , computer science , biology , genetics , mathematics , geometry

. Our understanding of the biology of organismal longevity is still limited. Using a genetic approach to identify genes and pathways that regulate longevity, we did a linked locus analysis for the trait longevity in the murine BXD recombinant inbred set of strains. Based on previous observations that pointed towards a correlation between the hematopoietic system and lifespan 1,2 , we also compared these results to a linked locus analysis for multiple quantitative traits that affect the hematopoietic stem cell system in young and old animals. With this comparative method we uncover a network of pathways regulating both the hematopoietic stem cell system and longevity.

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