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The type VI secretion system (T6SS) is bacterial protein injection machinery with roles in virulence, symbiosis, interbacterial interaction, antipathogenesis, and environmental stress responses. There are two T6SS loci, T6SS1 and T6SS2, in the two chromosomes of  Vibrio parahaemolyticus , respectively. This work disclosed that the master quorum sensing (QS) regulator OpaR repressed the transcription of  hcp1  encoding the structural component Hcp1 of T6SS1 in  V. parahaemolyticus , indicating that QS had a negative regulatory action on T6SS1. A single  σ   54 -dependent promoter was transcribed for  hcp1  in  V. parahaemolyticus , and its activity was repressed by the OpaR regulator. Since the OpaR protein could not bind to the upstream region of  hcp1 , OpaR would repress the transcription of  hcp1  in an indirect manner.

Expression of the Type VI Secretion System 1 Component Hcp1 Is Indirectly Repressed by OpaR inVibrio parahaemolyticus