Open AccessAntinociceptive Activity of Ethanol Extract fromDuguetia chrysocarpaMaas (Annonaceae)
Author(s) -
Jackson Roberto Guedes da Silva Almeida,
Edigênia Cavalcante da Cruz Araújo,
Luciano Augusto de Araújo Ribeiro,
Julianeli Tolentino de Lima,
Xirley Pereira Nunes,
Ana Sílvia Suassuna Carneiro Lúcio,
Maria de Fátima Agra,
José Maria BarbosaFilho
Publication year - 2012
Publication title -
the scientific world journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.453
H-Index - 93
eISSN - 2356-6140
pISSN - 1537-744X
DOI - 10.1100/2012/859210
Subject(s) - nociception , ethanol , phytochemical , chemistry , annonaceae , hot plate test , acetic acid , pharmacology , traditional medicine , medicine , biochemistry , receptor
The ethanol extract from the fruits of Duguetia chrysocarpa was evaluated for its antinociceptive activity in chemical and thermal models of nociception in mice. The intraperitoneal administration of the ethanol extract (100, 200, and 400 mg/kg body weight) showed a dose-dependent inhibition of acetic-acid-induced abdominal writhes. The extract also produced a significant inhibition of both phases of the formalin test in all doses tested and increased the reaction time in hot-plate test at dose of 200 mg/kg. The data obtained suggest that the antinociceptive effect of the extract may be mediated via both peripheral and central mechanisms. The phytochemical investigation yielded the isolation of the benzenoid derivative 3-methoxy-4-ethoxy benzoic acid which is being reported for the first time in this genus.
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