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Purpose . To compare central macular thickness (CMT) measurement on healthy patient using 3 different OCT devices by two operators.  Methods . Prospective, monocentricstudy. Right eye's central macular thickness (CMT) of 30 healthy patients has been measured three times using a time-domain (TD) OCT (Stratus OCT, Carl Zeiss Meditec, Dublin, Ca) and two spectral domain (SD) OCTs (Cirrus HD-OCT, Carl ZeissMeditec, Dublin, Ca) and 3D-OCT 1000 (Topcon, Tokyo, Japan) by two operators. Six measurements were taken randomly for each patient the same day.  Results . No significant difference between measurements obtained by the two operators has been observed, whatever the studied OCT.  P  value was 0.164, 0.193, and 0.147 for Stratus OCT, Cirrus HD-OCT and 3D-OCT, respectively. Mean CMT significantly differed from instrument to instrument ( P  < 0.001) and was, respectively, 197   μ  m, 254   μ  m, and 236   μ  m using Stratus OCT, Cirrus HD-OCT, and 3D-OCT 1000. Using Cirrus OCT and 3D-OCT 1000, CMT was, respectively, 57   μ  m and 39   μ  m thicker than using Stratus OCT ( P  < 0.05).  Conclusions . Whatever the OCT device, on healthy patients CMT was not operator dependent. CMT measurements obtained by SD-OCTs are greater than those obtained by TD-OCT. These data imply that the different OCT devices cannot be used interchangeably in clinical monitoring.

Comparison of Central Macular Thickness Measured by Three OCT Models and Study of Interoperator Variability