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. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of  Aloe vera  cream and  Calendula officinalis  ointment on the frequency and severity of DD in children.  Methods . Sixty-six infants with DD (aged < 3 years) were randomized to receive either  Aloe  cream ( n  = 32) or  Calendula  ointment ( n  = 34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial.  Results . Although improvement in the severity of DD was observed in both treatment groups ( P  < 0.001), patients receiving  Calendula  ointment had significantly fewer rash sites compared to  Aloe  group ( P  = 0.001). No adverse effect was reported from either of the medications.  Discussion . The evidence from this study suggests that topical  Aloe  and in particular  Calendula  could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.

A Randomized Comparative Trial on the Therapeutic Efficacy of TopicalAloe veraandCalendula officinalison Diaper Dermatitis in Children