Effect of ADH II Deficiency on the Intracellular Redox Homeostasis inZymomonas mobilis | Zendy

Ņina Gaļiņina | Zendy; Zane Ļaša | Zendy; Inese Strazdiņa | Zendy; Reinis Rutkis | Zendy; Uldis Kalnenieks | Zendy

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Effect of ADH II Deficiency on the Intracellular Redox Homeostasis inZymomonas mobilis

Author(s) -

Ņina Gaļiņina,

Zane Ļaša,

Inese Strazdiņa,

Reinis Rutkis,

Uldis Kalnenieks

Publication year - 2012

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/2012/742610

Subject(s) - zymomonas mobilis , intracellular , alcohol dehydrogenase , hydrogen peroxide , catalase , anaerobic exercise , nad+ kinase , biochemistry , chemistry , homeostasis , redox , biology , ethanol , enzyme , microbiology and biotechnology , ethanol fuel , physiology , organic chemistry

Mutant strain of the facultatively anaerobic, ethanol-producing bacterium Zymomonas mobilis , deficient in the Fe-containing alcohol dehydrogenase isoenzyme (ADH II), showed impaired homeostasis of the intracellular NAD(P)H during transition from anaerobic to aerobic conditions, and also in steady-state continuous cultures at various oxygen supplies. At the same time, ADH II deficiency in aerobically grown cells was accompanied by a threefold increase of catalase activity and by about 50% increase of hydrogen peroxide excretion. It is concluded that ADH II under aerobic conditions functions to maintain intracellular redox homeostasis and to protect the cells from endogenous hydrogen peroxide.

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