Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model | Zendy

Rafael Ramírez Romero | Zendy; Alicia M. Nevárez-Garza | Zendy; Luis E. Rodríguez-Tovar | Zendy; Alfredo Wong-González | Zendy; Rogelio A. Ledezma-Torres | Zendy; Gustavo Hernández-Vidal | Zendy

Open Access

Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

Author(s) -

Rafael Ramírez Romero,

Alicia M. Nevárez-Garza,

Luis E. Rodríguez-Tovar,

Alfredo Wong-González,

Rogelio A. Ledezma-Torres,

Gustavo Hernández-Vidal

Publication year - 2012

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/2012/647403

Subject(s) - bronchiolitis obliterans , medicine , bronchiectasis , metaplasia , pathology , pneumonia , chronic bronchitis , bronchitis , lung , copd , bronchiolitis obliterans organizing pneumonia , animal model , bronchiolitis , respiratory system , lung transplantation

Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP) and chronic obstructive pulmonary disease (COPD) in human beings, calves are proposed as an alternative animal model.

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