Central Precocious Puberty: Treatment with Triptorelin 11.25 mg

Background . Few data are available on quarterly 11.25 mg GnRH analog treatment in central precocious puberty (CPP). Aim . To assess the efficacy of triptorelin 11.25 mg in children with CPP. Patients . 17 patients (16 females) with CPP (7.9 ± 0.9 years) were treated with triptorelin 11.25 mg/90 days. Methods . Gonadotropins, basal-, and GnRH-stimulated peak, gonadal steroids, and pubertal signs were assessed at preinclusion and at inclusion visit, 3 months, 6 months, and 12 months of treatment. Results . At 3, 6, and 12 months, all patients had suppressed LH peak (<3 IU/L after GnRH stimulation), as well as prepubertal oestradiol levels. Mean LH peak values after GnRH test significantly decreased from 25.7 ± 16.5 IU/L at baseline to 0.9 ± 0.5 IU/L at M3 ( P < 0.0001); they did not significantly changed at M6 and M12. Conclusions . Triptorelin 11.25 mg/90 days efficiently suppressed the pituitary-gonadal axis in children with CPP from first administration.