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In this prospective, case-control genetic study, 120 consecutive neovascular age-related macular degeneration (AMD) cases and 78 controls were enrolled. Two SNPs (rs2071559 and rs1870377) of  VEGF-A  receptor-2 ( VEGFR-2 ) gene were analyzed with the technique of Real-Time PCR to investigate a genetic link between AMD and  VEGFR-2  gene polymorphisms in Italian patients. The frequency of the  VEGFR-2  genotype rs2071559 AA was significantly lower (18.33%) in patients with AMD than in the control subjects (34.62%;  P  = 0.0095, chi-square test;  P   corr  = 0.038; OR = 0.42, 95% CI 0.22 to 0.82). In conclusion, although with the limitations of a small sample size and the few SNPs studied, this study demonstrates a lower frequency of  VEGFR-2  rs2071559 AA genotype in an AMD patient population, suggesting future studies on the role  VEGFR-2  SNPs.

The rs2071559 AAVEGFR-2Genotype Frequency Is Significantly Lower in Neovascular Age-Related Macular Degeneration Patients