Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications | Zendy

Seung-Ick Oh | Zendy; Chang Kyu Lee | Zendy; Kyung Jin Cho | Zendy; Kyung-Ok Lee | Zendy; SsangGoo Cho | Zendy; Sunghoi Hong | Zendy

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Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications

Author(s) -

Seung-Ick Oh,

Chang Kyu Lee,

Kyung Jin Cho,

Kyung-Ok Lee,

SsangGoo Cho,

Sunghoi Hong

Publication year - 2012

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/2012/417809

Subject(s) - reprogramming , induced pluripotent stem cell , somatic cell , transduction (biophysics) , stem cell , biology , computational biology , regenerative medicine , microbiology and biotechnology , cell , embryonic stem cell , genetics , gene , biochemistry

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is achieved by viral-mediated transduction of defined transcription factors. Generation of iPSCs is of great medical interest as they have the potential to be a source of patient-specific cells. For the eventual goal of clinical application, it is necessary to overcome the limitations of low reprogramming efficiency and chromosomal abnormalities due to viral DNA integration. In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.

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