Colorectal Cancer Chemoprevention: Is This the Future of Colorectal Cancer Prevention? | Zendy

Aránzazu Manzano | Zendy; Pedro PérezSegura | Zendy

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Colorectal Cancer Chemoprevention: Is This the Future of Colorectal Cancer Prevention?

Author(s) -

Aránzazu Manzano,

Pedro PérezSegura

Publication year - 2012

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/2012/327341

Subject(s) - colorectal cancer , medicine , nonsteroidal , cancer , cancer prevention , chemoprophylaxis , causes of cancer , oncology , intensive care medicine , bioinformatics , biology

Colorectal cancer (CRC) is presently one of the most common causes of cancer-related death in our setting and affects a great number of people each year. Screening strategies are commonly used but they do not seem enough to avoid CRC development or prevent completely its mortality. Because of this fact other prevention strategies have gained interest in recent years. Chemoprevention seems to be an attractive option in this setting and several drugs have been studied in this field. This review is focused on salicylates, nonsteroidal anti-inflammatory drugs (NSAIDs) and cycloxygenase-2 inhibitors (COXIBs), whose mechanism of action could be directly related to colon cancer chemoprevention.

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