CD8+T Cells: GITR Matters | Zendy

Simona Ronchetti | Zendy; Giuseppe Nocentini | Zendy; Maria Grazia Petrillo | Zendy; Carlo Riccardi | Zendy

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CD8⁺T Cells: GITR Matters

Author(s) -

Simona Ronchetti,

Giuseppe Nocentini,

Maria Grazia Petrillo,

Carlo Riccardi

Publication year - 2012

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/2012/308265

Subject(s) - immune system , cd8 , cytotoxic t cell , biology , microbiology and biotechnology , function (biology) , immunity , tumor necrosis factor alpha , immunology , cancer research , in vitro , genetics

As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8 + T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8 + cells, paying particular attention to numerous and recent studies that suggest its crucial role in mouse disease models.

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