In VitroAntibacterial and Antifungal Activity of Salicylanilide Benzoates | Zendy

Martin Krátký | Zendy; Jarmila Vinšová | Zendy; Vladimı́r Buchta | Zendy

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In VitroAntibacterial and Antifungal Activity of Salicylanilide Benzoates

Author(s) -

Martin Krátký,

Jarmila Vinšová,

Vladimı́r Buchta

Publication year - 2012

Publication title -

the scientific world journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.453

H-Index - 93

eISSN - 2356-6140

pISSN - 1537-744X

DOI - 10.1100/2012/290628

Subject(s) - benzoates , antimicrobial , benzoic acid , antifungal , in vitro , minimum inhibitory concentration , staphylococcus aureus , antibacterial activity , chemistry , microbiology and biotechnology , bacteria , biology , organic chemistry , biochemistry , genetics

The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl)phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations ≥0.98 μ mol/L including methicillin-resistant Staphylococcus aureus strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)phenyl benzoate. The antifungal activity is significantly lower.

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